Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A.

Lei, Yu; Han, Ping; Chen, Yu; Wang, Han; Wang, Shuhui; Wang, Muru; Liu, Jingmei; Yan, Wei; Tian, Dean; Liu, Mei

Lei, Yu; Han, Ping; Chen, Yu; Wang, Han; Wang, Shuhui; Wang, Muru; Liu, Jingmei; Yan, Wei; Tian, Dean; Liu, Mei.

Afiliação

Lei Y; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Han P; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Chen Y; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Wang H; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Wang S; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Wang M; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Liu J; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Yan W; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Tian D; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Liu M; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Clin Transl Med ; 12(1): e686, 2022 01.

Article em En | MEDLINE | ID: mdl-35090076

Assuntos

Carcinoma Hepatocelular/tratamento farmacológico; Glicólise/efeitos dos fármacos; L-Lactato Desidrogenase/farmacologia; Proteína-Arginina N-Metiltransferases/farmacologia; Animais; Linhagem Celular Tumoral/efeitos dos fármacos; Linhagem Celular Tumoral/metabolismo; Proliferação de Células/efeitos dos fármacos; China; Modelos Animais de Doenças; Histologia/instrumentação; Histologia/tendências; Humanos; L-Lactato Desidrogenase/metabolismo; Neoplasias Hepáticas/tratamento farmacológico; Metilação/efeitos dos fármacos; Camundongos; Proteína-Arginina N-Metiltransferases/metabolismo

Palavras-chave

glycolysis; hepatocellular carcinoma (HCC); lactate dehydrogenase A (LDHA); protein arginine methyltransferase 3 (PRMT3)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Carcinoma Hepatocelular / Glicólise / L-Lactato Desidrogenase Limite: Animals / Humans País/Região como assunto: Asia Idioma: En Revista: Clin Transl Med Ano de publicação: 2022 Tipo de documento: Article

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