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Nerve ultrasound detects abnormally small nerves in patients with spinal and bulbar muscular atrophy.
Pelosi, Luciana; Ghosh, Avroneel; Leadbetter, Ruth; Lance, Sean; Rodrigues, Miriam; Roxburgh, Richard.
Afiliação
  • Pelosi L; Departments of Neurology and Neurophysiology, Bay Of Plenty District Health Board, Tauranga Hospital, Tauranga, New Zealand.
  • Ghosh A; Department of Neurology, Auckland District Health Board, Auckland, New Zealand.
  • Leadbetter R; Department of Neurology, Wellington Hospital, Wellington, New Zealand.
  • Lance S; Department of Neurology, Wellington Hospital, Wellington, New Zealand.
  • Rodrigues M; Department of Neurology, Auckland District Health Board, Auckland, New Zealand.
  • Roxburgh R; Department of Neurology, Auckland District Health Board, Auckland, New Zealand.
Muscle Nerve ; 65(5): 599-602, 2022 05.
Article em En | MEDLINE | ID: mdl-35092036
INTRODUCTION/AIMS: Sensory impairment secondary to dorsal root ganglion neuronopathy is common, although often subclinical, in X-linked spinal and bulbar muscular atrophy (SBMA). We investigated the hypothesis that nerves of SBMA patients show the same morphological changes on ultrasound as other inherited sensory neuronopathies and that these changes are distinct from those in axonal neuropathy. METHODS: We compared the ultrasound cross-sectional areas (CSAs) of median, ulnar, sural, and tibial nerves of prospectively recruited SBMA patients with those of patients with acquired axonal neuropathy and healthy controls. We also compared the individual nerve CSAs of SBMA and neuropathy patients with our laboratory reference values. RESULTS: There were 7 SBMA patients, 18 neuropathy patients, and 42 healthy controls. The nerve CSAs of the SBMA patients were significantly smaller than those of patients in the other two groups. The changes were most prominent in the upper limbs (p < .001), with the nerves of the SBMA patients being on average approximately half the size of the controls and a third the size of the neuropathy patients. On individual analysis, the ultrasound abnormality was sufficiently characteristic to be detected in all but one SBMA patient. DISCUSSION: These ultrasound changes are similar to those reported in other inherited sensory neuronopathies and clearly different from the ultrasound findings in axonal neuropathy. Smaller nerves are possibly a distinctive finding in SBMA that may distinguish it from other motor neuron syndromes. Further studies are warranted to confirm this and determine the optimal sonographic protocol.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atrofia Muscular Espinal / Doenças do Sistema Nervoso Periférico / Atrofia Bulboespinal Ligada ao X Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Muscle Nerve Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atrofia Muscular Espinal / Doenças do Sistema Nervoso Periférico / Atrofia Bulboespinal Ligada ao X Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Muscle Nerve Ano de publicação: 2022 Tipo de documento: Article