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DNA Based Vaccine Expressing SARS-CoV-2 Spike-CD40L Fusion Protein Confers Protection Against Challenge in a Syrian Hamster Model.
Tamming, Levi A; Duque, Diana; Tran, Anh; Zhang, Wanyue; Pfeifle, Annabelle; Laryea, Emmanuel; Wu, Jianguo; Raman, Sathya N Thulasi; Gravel, Caroline; Russell, Marsha S; Hashem, Anwar M; Alsulaiman, Reem M; Alhabbab, Rowa Y; Gao, Jun; Safronetz, David; Cao, Jingxin; Wang, Lisheng; Chen, Wangxue; Johnston, Michael J W; Sauve, Simon; Rosu-Myles, Michael; Li, Xuguang.
Afiliação
  • Tamming LA; Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada.
  • Duque D; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
  • Tran A; Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, ON, Canada.
  • Zhang W; Human Health Therapeutics Research Center, National Research Council of Canada, Ottawa, ON, Canada.
  • Pfeifle A; Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada.
  • Laryea E; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
  • Wu J; Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada.
  • Raman SNT; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
  • Gravel C; Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada.
  • Russell MS; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
  • Hashem AM; Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada.
  • Alsulaiman RM; Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada.
  • Alhabbab RY; Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada.
  • Gao J; Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada.
  • Safronetz D; Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Cao J; Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Wang L; Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Chen W; Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Johnston MJW; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Sauve S; Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals, Ottawa, ON, Canada.
  • Rosu-Myles M; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
  • Li X; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Front Immunol ; 12: 785349, 2021.
Article em En | MEDLINE | ID: mdl-35095861
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 4_TD Base de dados: MEDLINE Assunto principal: Mesocricetus / Vacinas de DNA / Ligante de CD40 / Glicoproteína da Espícula de Coronavírus / SARS-CoV-2 / COVID-19 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 4_TD Base de dados: MEDLINE Assunto principal: Mesocricetus / Vacinas de DNA / Ligante de CD40 / Glicoproteína da Espícula de Coronavírus / SARS-CoV-2 / COVID-19 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2021 Tipo de documento: Article