Developmental thyroid disruption permanently affects the neuroglial output in the murine subventricular zone.
Stem Cell Reports
; 17(3): 459-474, 2022 03 08.
Article
em En
| MEDLINE
| ID: mdl-35120623
ABSTRACT
Neural stem cells (NSCs) in the adult brain are a source of neural cells for brain injury repair. We investigated whether their capacity to generate new neurons and glia is determined by thyroid hormone (TH) during development because serum levels peak during postnatal reorganization of the main NSC niche, the subventricular zone (SVZ). Re-analysis of mouse transcriptome data revealed increased expression of TH transporters and deiodinases in postnatal SVZ NSCs, promoting local TH action, concomitant with a burst in neurogenesis. Inducing developmental hypothyroidism reduced NSC proliferation, disrupted expression of genes implicated in NSC determination and TH signaling, and altered the neuron/glia output in newborns. Three-month-old adult mice recovering from developmental hypothyroidism had fewer olfactory interneurons and underperformed on short-memory odor tests, dependent on SVZ neurogenesis. Our data provide readouts permitting comparison with adverse long-term events following thyroid disruptor exposure and ideas regarding the etiology of prevalent neurodegenerative diseases in industrialized countries.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ventrículos Laterais
/
Hipotireoidismo
Limite:
Animals
Idioma:
En
Revista:
Stem Cell Reports
Ano de publicação:
2022
Tipo de documento:
Article