Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-&#954;B p65/LIF/STAT3 pathways in olfactory bulbectomized mice.

Takahashi, Kohei; Kurokawa, Kazuhiro; Hong, Lihua; Miyagawa, Kazuya; Mochida-Saito, Atsumi; Iwasa, Masahiro; Iwasa, Hiroyuki; Nakagawasai, Osamu; Tadano, Takeshi; Takeda, Hiroshi; Tsuji, Minoru

Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice.

Takahashi, Kohei; Kurokawa, Kazuhiro; Hong, Lihua; Miyagawa, Kazuya; Mochida-Saito, Atsumi; Iwasa, Masahiro; Iwasa, Hiroyuki; Nakagawasai, Osamu; Tadano, Takeshi; Takeda, Hiroshi; Tsuji, Minoru.

Afiliação

Takahashi K; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan.
Kurokawa K; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan.
Hong L; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan.
Miyagawa K; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan.
Mochida-Saito A; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan.
Iwasa M; Nihon Berm Co, Ltd, 2-14-3 Nagatachou, Chiyoda-ku, Tokyo, 100-0014, Japan.
Iwasa H; Nihon Berm Co, Ltd, 2-14-3 Nagatachou, Chiyoda-ku, Tokyo, 100-0014, Japan.
Nakagawasai O; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan.
Tadano T; Complementary and Alternative Medicine Clinical Research and Development, Graduate School of Medicine Sciences, Kanazawa University, Kanazawa, 920-8640, Japan.
Takeda H; Department of Pharmacology, School of Pharmacy at Fukuoka, International University of Health and Welfare, 137-1 Enokizu, Okawa, Fukuoka, 831-8501, Japan.
Tsuji M; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan. Electronic address: mtsuji@iuhw.ac.jp.

J Psychiatr Res ; 148: 137-148, 2022 04.

Article em En | MEDLINE | ID: mdl-35123326

Assuntos

Fator Neurotrófico Derivado do Encéfalo; Transtorno Depressivo Maior; Animais; Antidepressivos/uso terapêutico; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/farmacologia; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/uso terapêutico; Depressão/tratamento farmacológico; Transtorno Depressivo Maior/tratamento farmacológico; Modelos Animais de Doenças; Enterococcus faecalis/metabolismo; Hipocampo; Humanos; Fator Inibidor de Leucemia/metabolismo; Fator Inibidor de Leucemia/farmacologia; Fator Inibidor de Leucemia/uso terapêutico; Camundongos; NF-kappa B/metabolismo; NF-kappa B/farmacologia; NF-kappa B/uso terapêutico; Bulbo Olfatório/metabolismo; Bulbo Olfatório/cirurgia; Córtex Pré-Frontal/metabolismo; Fator de Transcrição STAT3/metabolismo; Fator de Transcrição STAT3/farmacologia; Fator de Transcrição STAT3/uso terapêutico

Palavras-chave

Depression; EF-2001; Myelin; Olfactory bulbectomy; Oligodendrocyte; Prefrontal cortex

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Transtorno Depressivo Maior Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Psychiatr Res Ano de publicação: 2022 Tipo de documento: Article

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