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NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation.
Sharrock, Abigail V; Mulligan, Timothy S; Hall, Kelsi R; Williams, Elsie M; White, David T; Zhang, Liyun; Emmerich, Kevin; Matthews, Frazer; Nimmagadda, Saumya; Washington, Selena; Le, Katherine D; Meir-Levi, Danielle; Cox, Olivia L; Saxena, Meera T; Calof, Anne L; Lopez-Burks, Martha E; Lander, Arthur D; Ding, Ding; Ji, Hongkai; Ackerley, David F; Mumm, Jeff S.
Afiliação
  • Sharrock AV; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.
  • Mulligan TS; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Hall KR; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.
  • Williams EM; School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.
  • White DT; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Zhang L; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Emmerich K; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Matthews F; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Nimmagadda S; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Washington S; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Le KD; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Meir-Levi D; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Cox OL; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Saxena MT; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
  • Calof AL; Luminomics, Baltimore, MD, USA.
  • Lopez-Burks ME; Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA.
  • Lander AD; Department of Developmental and Cell Biology, University of California, Irvine, CA, USA.
  • Ding D; Center for Complex Biological Systems, University of California, Irvine, CA, USA.
  • Ji H; Department of Developmental and Cell Biology, University of California, Irvine, CA, USA.
  • Ackerley DF; Center for Complex Biological Systems, University of California, Irvine, CA, USA.
  • Mumm JS; Department of Developmental and Cell Biology, University of California, Irvine, CA, USA.
Nat Methods ; 19(2): 205-215, 2022 02.
Article em En | MEDLINE | ID: mdl-35132245
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nitrorredutases / Pró-Fármacos / Metronidazol Limite: Animals / Humans Idioma: En Revista: Nat Methods Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nitrorredutases / Pró-Fármacos / Metronidazol Limite: Animals / Humans Idioma: En Revista: Nat Methods Ano de publicação: 2022 Tipo de documento: Article