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Fibrinogen aptamer functionalized gold-coated iron-oxide nanoparticles for targeted imaging of thrombi.
Koudrina, Anna; Chartrand, Celine; Cron, Greg O; O'Brien, Jonathan; Tsai, Eve C; DeRosa, Maria C.
Afiliação
  • Koudrina A; Department of Chemistry, Carleton University, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada. maria.derosa@carleton.ca.
  • Chartrand C; Department of Chemistry, Carleton University, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada. maria.derosa@carleton.ca.
  • Cron GO; Ottawa Hospital Research Institute, 1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada.
  • O'Brien J; Faculty of Medicine, University of Ottawa, 75 Laurier Ave. E, Ottawa, ON K1N 6N5, Canada.
  • Tsai EC; The Ottawa Hospital, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada.
  • DeRosa MC; The Ottawa Hospital, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada.
Chem Commun (Camb) ; 58(17): 2870-2873, 2022 Feb 24.
Article em En | MEDLINE | ID: mdl-35132974
ABSTRACT
Targeting of molecular constituents of thrombi with aptamer functionalized core-shell nanoparticles (CSN) allowed for high resolution clot delineation in T2-weighted magnetic resonance imaging. Meanwhile, the gold-coating demonstrated sufficient contrast capabilities in computed tomography (1697 HU µM-1). This targeted CSN formulation could allow for precise imaging of blood clots at low nanomolar concentrations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Fibrinogênio / Imageamento por Ressonância Magnética / Aptâmeros de Nucleotídeos / Nanopartículas Magnéticas de Óxido de Ferro / Ouro Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Fibrinogênio / Imageamento por Ressonância Magnética / Aptâmeros de Nucleotídeos / Nanopartículas Magnéticas de Óxido de Ferro / Ouro Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2022 Tipo de documento: Article