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Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.
Benýsek, Jakub; Busa, Michal; Rubesová, Petra; Fanfrlík, Jindrich; Lepsík, Martin; Brynda, Jirí; Matousková, Zuzana; Bartz, Ulrike; Horn, Martin; Gütschow, Michael; Mares, Michael.
Afiliação
  • Benýsek J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
  • Busa M; First Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Rubesová P; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
  • Fanfrlík J; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
  • Lepsík M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
  • Brynda J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
  • Matousková Z; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
  • Bartz U; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
  • Horn M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
  • Gütschow M; Department of Natural Sciences, University of Applied Sciences Bonn-Rhein-Sieg, Rheinbach, Germany.
  • Mares M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
J Enzyme Inhib Med Chem ; 37(1): 515-526, 2022 Dec.
Article em En | MEDLINE | ID: mdl-35144520
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Catepsina K / Hidrazinas / Nitrilas Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Catepsina K / Hidrazinas / Nitrilas Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Ano de publicação: 2022 Tipo de documento: Article