A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells.

Sofer, Summer; Lamkiewicz, Kevin; Armoza Eilat, Shir; Partouche, Shirly; Marz, Manja; Moskovits, Neta; Stemmer, Salomon M; Shlomai, Amir; Sklan, Ella H

Sofer, Summer; Lamkiewicz, Kevin; Armoza Eilat, Shir; Partouche, Shirly; Marz, Manja; Moskovits, Neta; Stemmer, Salomon M; Shlomai, Amir; Sklan, Ella H.

Afiliação

Sofer S; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Lamkiewicz K; RNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University, Jena, Germany.
Armoza Eilat S; European Virus Bioinformatics Center, Jena, Germany.
Partouche S; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Marz M; Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel.
Moskovits N; RNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University, Jena, Germany.
Stemmer SM; European Virus Bioinformatics Center, Jena, Germany.
Shlomai A; Leibniz Institute for Age Research-Fritz Lipmann Institute, Jena, Germany.
Sklan EH; PDX Laboratory, Felsenstein Medical Research Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

FASEB J ; 36(3): e22191, 2022 03.

Article em En | MEDLINE | ID: mdl-35147243

Assuntos

Carcinoma Hepatocelular/metabolismo; Resistencia a Medicamentos Antineoplásicos; Hexoquinase/metabolismo; Neoplasias Hepáticas/metabolismo; Animais; Antineoplásicos/uso terapêutico; Carcinoma Hepatocelular/tratamento farmacológico; Linhagem Celular Tumoral; Células Cultivadas; Hexoquinase/genética; Humanos; Neoplasias Hepáticas/tratamento farmacológico; Masculino; Camundongos; Camundongos Endogâmicos NOD; Mutação; Inibidores de Proteínas Quinases/uso terapêutico; Regulação para Cima

Palavras-chave

CRISPR activation; hepatocellular carcinoma; tyrosine-kinase inhibitors

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Resistencia a Medicamentos Antineoplásicos / Hexoquinase / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: FASEB J Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google