The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism.

Ruiz-Serrano, Amalia; Boyle, Christina N; Monné Rodríguez, Josep M; Günter, Julia; Jucht, Agnieszka E; Pfundstein, Svende; Bapst, Andreas M; Lutz, Thomas A; Wenger, Roland H; Scholz, Carsten C

Ruiz-Serrano, Amalia; Boyle, Christina N; Monné Rodríguez, Josep M; Günter, Julia; Jucht, Agnieszka E; Pfundstein, Svende; Bapst, Andreas M; Lutz, Thomas A; Wenger, Roland H; Scholz, Carsten C.

Afiliação

Ruiz-Serrano A; Institute of Physiology, University of Zurich, 8057 Zurich, Switzerland.
Boyle CN; Institute of Veterinary Physiology, University of Zurich, 8057 Zurich, Switzerland.
Monné Rodríguez JM; Laboratory for Animal Model Pathology (LAMP), Institute of Veterinary Pathology, University of Zurich, 8057 Zurich, Switzerland.
Günter J; Institute of Physiology, University of Zurich, 8057 Zurich, Switzerland.
Jucht AE; National Centre of Competence in Research 'Kidney.CH', 8057 Zurich, Switzerland.
Pfundstein S; Institute of Physiology, University of Zurich, 8057 Zurich, Switzerland.
Bapst AM; Institute of Physiology, University of Zurich, 8057 Zurich, Switzerland.
Lutz TA; Institute of Physiology, University of Zurich, 8057 Zurich, Switzerland.
Wenger RH; Institute of Veterinary Physiology, University of Zurich, 8057 Zurich, Switzerland.
Scholz CC; Institute of Physiology, University of Zurich, 8057 Zurich, Switzerland.

Int J Mol Sci ; 23(3)2022 Jan 28.

Article em En | MEDLINE | ID: mdl-35163456

Assuntos

Trifosfato de Adenosina/metabolismo; Cisteína Endopeptidases/genética; Deleção de Genes; Resistência à Insulina/genética; Insulina/administração & dosagem; Oxigenases de Função Mista/metabolismo; Adenilato Quinase/metabolismo; Animais; Glicemia; Peso Corporal; Tamanho Celular; Células Cultivadas; Cisteína Endopeptidases/metabolismo; Metabolismo Energético; Fibroblastos/citologia; Fibroblastos/efeitos dos fármacos; Fibroblastos/metabolismo; Insulina/efeitos adversos; Camundongos; Fosforilação; Proteínas Proto-Oncogênicas c-akt/metabolismo

Palavras-chave

FIH; Hif1an; deubiquitinating enzyme; energy expenditure; hypoxia; insulin; liver; ubiquitin system

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Cisteína Endopeptidases / Trifosfato de Adenosina / Deleção de Genes / Oxigenases de Função Mista / Insulina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article

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