Visible-Light-Induced para-Difluoroalkylation of Aniline Derivatives.
J Org Chem
; 87(5): 3546-3554, 2022 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-35170321
ABSTRACT
Visible-light-induced, iridium catalyzed, para-selective C-H difluoroalkylation of aniline derivatives under mild reaction conditions is reported. Various substrates and bioactive compounds, such as precursors of vorinostat and chlorpropham, were all well tolerated. This protocol features a wide substrate scope, high regioselectivity, low catalyst usage, and operational simplicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2022
Tipo de documento:
Article