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Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis.
Hong, Hyebeen; Lee, Jongeun; Park, Guk-Yeol; Kim, Soeun; Park, Jiho; Park, Jong Seok; Song, Youngkwon; Lee, Sujin; Kim, Tae Jin; Lee, You Jeong; Roh, Tae-Young; Kwok, Seung-Ki; Kim, Sung Won; Tan, Qiumin; Lee, Yoontae.
Afiliação
  • Hong H; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea.
  • Lee J; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea.
  • Park GY; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea.
  • Kim S; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea.
  • Park J; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea.
  • Park JS; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea.
  • Song Y; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea.
  • Lee S; Department of Immunology, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea.
  • Kim TJ; Department of Immunology, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea.
  • Lee YJ; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea.
  • Roh TY; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea.
  • Kwok SK; Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
  • Kim SW; Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
  • Tan Q; Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
  • Lee Y; Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea. Electronic address: yoontael@postech.ac.kr.
Cell Rep ; 38(7): 110386, 2022 02 15.
Article em En | MEDLINE | ID: mdl-35172136
B-1 cell development mainly occurs via fetal and neonatal hematopoiesis and is suppressed in adult bone marrow hematopoiesis. However, little is known about the factors inhibiting B-1 cell development at the adult stage. We report that capicua (CIC) suppresses postnatal B-1a cell development and survival. CIC levels are high in B-1a cells and gradually increase in transitional B-1a (TrB-1a) cells with age. B-cell-specific Cic-null mice exhibit expansion of the B-1a cell population and a gradual increase in TrB-1a cell frequency with age but attenuated B-2 cell development. CIC deficiency enhances B cell receptor (BCR) signaling in transitional B cells and B-1a cell viability. Mechanistically, CIC-deficiency-mediated Per2 derepression upregulates Bhlhe41 levels by inhibiting CRY-mediated transcriptional repression for Bhlhe41, consequently promoting B-1a cell formation in Cic-null mice. Taken together, CIC is a key transcription factor that limits the B-1a cell population at the adult stage and balances B-1 versus B-2 cell formation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Transdução de Sinais / Subpopulações de Linfócitos B / Fatores de Transcrição Hélice-Alça-Hélice Básicos / Proteínas Circadianas Period Limite: Animals / Child / Child, preschool / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Transdução de Sinais / Subpopulações de Linfócitos B / Fatores de Transcrição Hélice-Alça-Hélice Básicos / Proteínas Circadianas Period Limite: Animals / Child / Child, preschool / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2022 Tipo de documento: Article