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Non-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-ß and Tau Pathology in Middle-Aged Adults: The Framingham Study.
Weinstein, Galit; O'Donnell, Adrienne; Davis-Plourde, Kendra; Zelber-Sagi, Shira; Ghosh, Saptaparni; DeCarli, Charles S; Thibault, Emma G; Sperling, Reisa A; Johnson, Keith A; Beiser, Alexa S; Seshadri, Sudha.
Afiliação
  • Weinstein G; School of Public Health, University of Haifa, Haifa, Israel.
  • O'Donnell A; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Davis-Plourde K; The Framingham Study, Framingham, MA, USA.
  • Zelber-Sagi S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Ghosh S; The Framingham Study, Framingham, MA, USA.
  • DeCarli CS; School of Public Health, University of Haifa, Haifa, Israel.
  • Thibault EG; Liver Unit, Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel.
  • Sperling RA; The Framingham Study, Framingham, MA, USA.
  • Johnson KA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
  • Beiser AS; Department of Neurology, School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Davis, CA, USA.
  • Seshadri S; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
J Alzheimers Dis ; 86(3): 1371-1383, 2022.
Article em En | MEDLINE | ID: mdl-35213373
ABSTRACT

BACKGROUND:

Liver steatosis and fibrosis are emerging as risk factors for multiple extrahepatic health conditions; however, their relationship with Alzheimer's disease pathology is unclear.

OBJECTIVE:

To examine whether non-alcoholic fatty liver disease (NAFLD) and FIB-4, a non-invasive index of advanced fibrosis, are associated with brain amyloid-ß (Aß) and tau pathology.

METHODS:

The study sample included Framingham Study participants from the Offspring and Third generation cohorts who attended exams 9 (2011-2014) and 2 (2008-2011), respectively. Participants underwent 11C-Pittsburgh Compound-B amyloid and 18F-Flortaucipir tau positron emission tomography (PET) imaging and abdomen computed tomography, or had information on all components of the FIB-4 index. Linear regression models were used to assess the relationship of NAFLD and FIB-4 with regional tau and Aß, adjusting for potential confounders and multiple comparisons.

RESULTS:

Of the subsample with NAFLD information (N = 169; mean age 52±9 y; 57% males), 57 (34%) had NAFLD. Of the subsample with information on liver fibrosis (N = 177; mean age 50±10 y; 51% males), 34 (19%) had advanced fibrosis (FIB-4 > 1.3). Prevalent NAFLD was not associated with Aß or tau PET. However, FIB-4 index was significantly associated with increased rhinal tau (ß= 1.03±0.33, p = 0.002). Among individuals with prevalent NAFLD, FIB-4 was related to inferior temporal, parahippocampal gyrus, entorhinal and rhinal tau (ß= 2.01±0.47, p < 0.001; ß= 1.60±0.53, p = 0.007, and ß= 1.59±0.47, p = 0.003 and ß= 1.60±0.42, p = 0.001, respectively) and to Aß deposition overall and in the inferior temporal and parahippocampal regions (ß= 1.93±0.47, p < 0.001; ß= 1.59±0.38, p < 0.001, and ß= 1.52±0.54, p = 0.008, respectively).

CONCLUSION:

This study suggests a possible association between liver fibrosis and early Alzheimer's disease pathology, independently of cardio-metabolic risk factors.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 8_ODS3_consumo_sustancias_psicoactivas Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: J Alzheimers Dis Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 8_ODS3_consumo_sustancias_psicoactivas Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: J Alzheimers Dis Ano de publicação: 2022 Tipo de documento: Article