Non-Alcoholic Fatty Liver Disease, Liver Fibrosis, and Regional Amyloid-ß and Tau Pathology in Middle-Aged Adults: The Framingham Study.
J Alzheimers Dis
; 86(3): 1371-1383, 2022.
Article
em En
| MEDLINE
| ID: mdl-35213373
ABSTRACT
BACKGROUND:
Liver steatosis and fibrosis are emerging as risk factors for multiple extrahepatic health conditions; however, their relationship with Alzheimer's disease pathology is unclear.OBJECTIVE:
To examine whether non-alcoholic fatty liver disease (NAFLD) and FIB-4, a non-invasive index of advanced fibrosis, are associated with brain amyloid-ß (Aß) and tau pathology.METHODS:
The study sample included Framingham Study participants from the Offspring and Third generation cohorts who attended exams 9 (2011-2014) and 2 (2008-2011), respectively. Participants underwent 11C-Pittsburgh Compound-B amyloid and 18F-Flortaucipir tau positron emission tomography (PET) imaging and abdomen computed tomography, or had information on all components of the FIB-4 index. Linear regression models were used to assess the relationship of NAFLD and FIB-4 with regional tau and Aß, adjusting for potential confounders and multiple comparisons.RESULTS:
Of the subsample with NAFLD information (Nâ=â169; mean age 52±9ây; 57% males), 57 (34%) had NAFLD. Of the subsample with information on liver fibrosis (Nâ=â177; mean age 50±10ây; 51% males), 34 (19%) had advanced fibrosis (FIB-4â>â1.3). Prevalent NAFLD was not associated with Aß or tau PET. However, FIB-4 index was significantly associated with increased rhinal tau (ß=â1.03±0.33, pâ=â0.002). Among individuals with prevalent NAFLD, FIB-4 was related to inferior temporal, parahippocampal gyrus, entorhinal and rhinal tau (ß=â2.01±0.47, pâ<â0.001; ß=â1.60±0.53, pâ=â0.007, and ß=â1.59±0.47, pâ=â0.003 and ß=â1.60±0.42, pâ=â0.001, respectively) and to Aß deposition overall and in the inferior temporal and parahippocampal regions (ß=â1.93±0.47, pâ<â0.001; ß=â1.59±0.38, pâ<â0.001, and ß=â1.52±0.54, pâ=â0.008, respectively).CONCLUSION:
This study suggests a possible association between liver fibrosis and early Alzheimer's disease pathology, independently of cardio-metabolic risk factors.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
8_ODS3_consumo_sustancias_psicoactivas
Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
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Hepatopatia Gordurosa não Alcoólica
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Alzheimers Dis
Ano de publicação:
2022
Tipo de documento:
Article