Cytokine induced 3-D organotypic psoriasis skin model demonstrates distinct roles for NF-&#954;B and JAK pathways in disease pathophysiology.

Todorovic, Viktor; McDonald, Heath A; Hoover, Paul; Wetter, Joseph B; Marinopoulos, Anastasia E; Woody, Clarissa L; Miller, Loan; Finkielsztein, Ariel; Dunstan, Robert W; Paller, Amy S; Honore, Prisca; Getsios, Spiro; Scott, Victoria E

Cytokine induced 3-D organotypic psoriasis skin model demonstrates distinct roles for NF-κB and JAK pathways in disease pathophysiology.

Todorovic, Viktor; McDonald, Heath A; Hoover, Paul; Wetter, Joseph B; Marinopoulos, Anastasia E; Woody, Clarissa L; Miller, Loan; Finkielsztein, Ariel; Dunstan, Robert W; Paller, Amy S; Honore, Prisca; Getsios, Spiro; Scott, Victoria E.

Afiliação

Todorovic V; AbbVie Inc, North Chicago, Illinois, USA.
McDonald HA; AbbVie Inc, North Chicago, Illinois, USA.
Hoover P; Department of Dermatology, Northwestern University, Chicago, Illinois, USA.
Wetter JB; AbbVie Inc, North Chicago, Illinois, USA.
Marinopoulos AE; AbbVie Inc, North Chicago, Illinois, USA.
Woody CL; AbbVie Inc, North Chicago, Illinois, USA.
Miller L; AbbVie Inc, North Chicago, Illinois, USA.
Finkielsztein A; Department of Dermatology, Northwestern University, Chicago, Illinois, USA.
Dunstan RW; AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Paller AS; Department of Dermatology, Northwestern University, Chicago, Illinois, USA.
Honore P; AbbVie Inc, North Chicago, Illinois, USA.
Getsios S; Department of Dermatology, Northwestern University, Chicago, Illinois, USA.
Scott VE; AbbVie Inc, North Chicago, Illinois, USA.

Exp Dermatol ; 31(7): 1036-1047, 2022 07.

Article em En | MEDLINE | ID: mdl-35213752

Assuntos

Interleucina-17; Psoríase; Animais; Humanos; Interleucina-17/metabolismo; Queratinócitos/metabolismo; NF-kappa B/metabolismo; Psoríase/metabolismo; Pele/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Fator de Necrose Tumoral alfa/farmacologia

Palavras-chave

ABT-317; IKK-2 inhibitor IV; IL-17A; IL-22; TNFα

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Interleucina-17 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Exp Dermatol Ano de publicação: 2022 Tipo de documento: Article

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