Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents.

Wu, Hu; Du, Chuanbiao; Xu, Yajie; Liu, Lige; Zhou, Xin; Ji, Qinggang

Wu, Hu; Du, Chuanbiao; Xu, Yajie; Liu, Lige; Zhou, Xin; Ji, Qinggang.

Afiliação

Wu H; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Du C; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Xu Y; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Liu L; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Zhou X; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Ji Q; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China. Electronic address: jiqing@swu.edu.cn.

Eur J Med Chem ; 233: 114208, 2022 Apr 05.

Article em En | MEDLINE | ID: mdl-35220015

Assuntos

Antifúngicos; Quitina Sintase; Antifúngicos/química; Candida albicans; Quitina/farmacologia; Desenho de Fármacos; Inibidores Enzimáticos/química; Testes de Sensibilidade Microbiana; Pirrolidinas/farmacologia; Relação Estrutura-Atividade

Palavras-chave

Antimycotic; Drug combination; Drug-resistant fungi; Spiro-quinolinone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quitina Sintase / Antifúngicos Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article

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