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SPINKs in Tumors: Potential Therapeutic Targets.
Liao, Chengcheng; Wang, Qian; An, Jiaxing; Zhang, Minglin; Chen, Jie; Li, Xiaolan; Xiao, Linlin; Wang, Jiajia; Long, Qian; Liu, Jianguo; Guan, Xiaoyan.
Afiliação
  • Liao C; Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
  • Wang Q; Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China.
  • An J; Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China.
  • Zhang M; Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Life Sciences Institute, Zunyi Medical University, Zunyi, China.
  • Chen J; Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
  • Li X; Department of Gastroenterology, Affiliated Baiyun Hospital of Guizhou Medical University, Guiyang, China.
  • Xiao L; Department of Urology, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, China.
  • Wang J; Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China.
  • Long Q; Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Life Sciences Institute, Zunyi Medical University, Zunyi, China.
  • Liu J; Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
  • Guan X; Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China.
Front Oncol ; 12: 833741, 2022.
Article em En | MEDLINE | ID: mdl-35223512
ABSTRACT
The serine protease inhibitor Kazal type (SPINK) family includes SPINK1-14 and is the largest branch in the serine protease inhibitor family. SPINKs play an important role in pancreatic physiology and disease, sperm maturation and capacitation, Nager syndrome, inflammation and the skin barrier. Evidence shows that the unregulated expression of SPINK1, 2, 4, 5, 6, 7, and 13 is closely related to human tumors. Different SPINKs exhibit various regulatory modes in different tumors and can be used as tumor prognostic markers. This article reviews the role of SPINK1, 2, 4, 5, 6, 7, and 13 in different human cancer processes and helps to identify new cancer treatment targets.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Oncol Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Oncol Ano de publicação: 2022 Tipo de documento: Article