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ALSUntangled #64: butyrates.
Sun, Yuyao; Bedlack, Richard; Armon, Carmel; Beauchamp, Morgan; Bertorini, Tulio; Bowser, Robert; Bromberg, Mark; Caress, James; Carter, Gregory; Crayle, Jesse; Cudkowicz, Merit E; Glass, Jonathan D; Jackson, Carlayne; Lund, Isaac; Martin, Sarah; Paganoni, Sabrina; Pattee, Gary; Ratner, Dylan; Salmon, Kristiana; Wicks, Paul.
Afiliação
  • Sun Y; Neurology Department, Duke University, Durham, NC, USA.
  • Bedlack R; Neurology Department, Duke University, Durham, NC, USA.
  • Armon C; Department of Neurology, Loma Linda University, Loma Linda, CA, USA.
  • Beauchamp M; Undergraduate, North Carolina State University, Raleigh, NC, USA.
  • Bertorini T; Neurology Department, University of Tennessee Health Science Center, Memphis, TN, USA.
  • Bowser R; Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
  • Bromberg M; Department of Neurology, University of Utah, Salt Lake City, UT, USA.
  • Caress J; Department of Neurology, Baptist Medical Center, Winston Salem, NC, USA.
  • Carter G; Department of Rehabilitation, Elson S. Floyd College of Medicine, Spokane, WA, USA.
  • Crayle J; Neurology Department, Washington University, St. Louis, MO, USA.
  • Cudkowicz ME; Neurology Department, Mass General Brigham Inc, Boston, MA, USA.
  • Glass JD; Neurology Department, Emory University, Atlanta, GA, USA.
  • Jackson C; Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Lund I; Student, Green Hope High School, Cary, NC, USA.
  • Martin S; Physical Therapy Program, Duke University, Durham, NC, USA.
  • Paganoni S; Neurology Department, Mass General Brigham Inc, Boston, MA, USA.
  • Pattee G; Department of Neurology, Nebraska Medical Center, Omaha, NE, USA.
  • Ratner D; Student, Longmeadow High School, Longmeadow, MA, USA.
  • Salmon K; Department of Neurology, Montreal Neurological Institute, Montreal Canada.
  • Wicks P; Independent Consultant, UK.
Amyotroph Lateral Scler Frontotemporal Degener ; 23(7-8): 638-643, 2022 11.
Article em En | MEDLINE | ID: mdl-35225121
ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review butyrate and its different chemical forms (butyrates). Butyrates have plausible mechanisms for slowing ALS progression and positive pre-clinical studies. One trial suggests that sodium phenylbutyrate (NaPB) in combination with Tauroursodeoxycholic acid (TUDCA) can slow ALS progression and prolong survival, but the specific contribution of NaPB toward this effect is unclear. Butyrates appear reasonably safe for use in humans. Based on the above information, we support a trial of a butyrate in PALS, but we cannot yet recommend one as a treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esclerose Lateral Amiotrófica Limite: Humans Idioma: En Revista: Amyotroph Lateral Scler Frontotemporal Degener Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esclerose Lateral Amiotrófica Limite: Humans Idioma: En Revista: Amyotroph Lateral Scler Frontotemporal Degener Ano de publicação: 2022 Tipo de documento: Article