Icarisid II rescues cognitive dysfunction via activation of Wnt/ß-catenin signaling pathway promoting hippocampal neurogenesis in APP/PS1 transgenic mice.

Xiao, Hong-He; Chen, Ji-Cong; Li, He; Li, Rui-Hai; Wang, Hai-Bo; Song, Hui-Peng; Li, Hong-Yan; Shan, Guo-Shun; Tian, Yu; Zhao, Yu-Meng; Tian, Jin-Ming; Yang, Jing-Xian

Xiao, Hong-He; Chen, Ji-Cong; Li, He; Li, Rui-Hai; Wang, Hai-Bo; Song, Hui-Peng; Li, Hong-Yan; Shan, Guo-Shun; Tian, Yu; Zhao, Yu-Meng; Tian, Jin-Ming; Yang, Jing-Xian.

Afiliação

Xiao HH; Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Chen JC; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Li H; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Li RH; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Wang HB; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Song HP; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Li HY; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Shan GS; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Tian Y; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Zhao YM; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Tian JM; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Yang JX; School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.

Phytother Res ; 36(5): 2095-2108, 2022 May.

Article em En | MEDLINE | ID: mdl-35230733

Assuntos

Doença de Alzheimer; Disfunção Cognitiva; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Animais; Disfunção Cognitiva/tratamento farmacológico; Flavonoides; Glicogênio Sintase Quinase 3 beta/metabolismo; Hipocampo; Camundongos; Camundongos Transgênicos; Neurogênese; Oligopeptídeos/metabolismo; Via de Sinalização Wnt; beta Catenina/metabolismo

Palavras-chave

Alzheimer's disease; Wnt/ß-catenin signaling pathway; chondriosome; icarisid II; neurogenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva Limite: Animals Idioma: En Revista: Phytother Res Ano de publicação: 2022 Tipo de documento: Article

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