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Targeting solute carriers to modulate receptor-ligand interactions.
Sijben, Hubert J; Superti-Furga, Giulio; IJzerman, Adriaan P; Heitman, Laura H.
Afiliação
  • Sijben HJ; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
  • Superti-Furga G; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Medical University of Vienna, 1090 Vienna, Austria; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
  • IJzerman AP; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
  • Heitman LH; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands; Oncode Institute, Leiden, The Netherlands. Electronic address: l.h.heitman@lacdr.leidenuniv.nl.
Trends Pharmacol Sci ; 43(5): 358-361, 2022 05.
Article em En | MEDLINE | ID: mdl-35232590
ABSTRACT
Solute carrier transporters (SLCs) limit receptor activation via uptake of extracellular ligands. Novel concepts are emerging that describe the modulation of intracellular and plasma membrane receptors by ligand influx and efflux via SLCs, respectively. Here, we evaluate recent insights and provide an outlook for developing potential therapeutic strategies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Proteínas Carreadoras de Solutos Limite: Humans Idioma: En Revista: Trends Pharmacol Sci Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Proteínas Carreadoras de Solutos Limite: Humans Idioma: En Revista: Trends Pharmacol Sci Ano de publicação: 2022 Tipo de documento: Article