Targeting solute carriers to modulate receptor-ligand interactions.
Trends Pharmacol Sci
; 43(5): 358-361, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-35232590
ABSTRACT
Solute carrier transporters (SLCs) limit receptor activation via uptake of extracellular ligands. Novel concepts are emerging that describe the modulation of intracellular and plasma membrane receptors by ligand influx and efflux via SLCs, respectively. Here, we evaluate recent insights and provide an outlook for developing potential therapeutic strategies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Proteínas Carreadoras de Solutos
Limite:
Humans
Idioma:
En
Revista:
Trends Pharmacol Sci
Ano de publicação:
2022
Tipo de documento:
Article