C1q+ macrophages: passengers or drivers of cancer progression.
Trends Cancer
; 8(7): 517-526, 2022 07.
Article
em En
| MEDLINE
| ID: mdl-35288093
ABSTRACT
The omics era made possible the quest for efficient markers for cancer progression and revealed that macrophage populations are much more complex than just the M1/M2 dichotomy. Complement C1q pops up as a marker of a tolerogenic and immunosuppressive macrophage populations in both healthy and tumor tissues, but the specific role of C1q+ tumor-associated macrophages (TAM) is poorly understood. C1q is co-expressed in healthy and tumor macrophages with human leukocyte antigen DR (HLA-DR), Apolipoprotein E (APOE), and mannose receptor C-type 1 (MRC1) (CD206), suggesting a resident origin of this population. TAM expressing C1q correlate with T cell exhaustion and poor prognosis in numerous cancers. Herein, we discuss the plural roles of C1q in these macrophages and how it could drive cancer progression.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complemento C1q
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Trends Cancer
Ano de publicação:
2022
Tipo de documento:
Article