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A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variants.
Jiang, Linglei; Driedonks, Tom A P; Jong, Wouter S P; Dhakal, Santosh; Bart van den Berg van Saparoea, H; Sitaras, Ioannis; Zhou, Ruifeng; Caputo, Christopher; Littlefield, Kirsten; Lowman, Maggie; Chen, Mengfei; Lima, Gabriela; Gololobova, Olesia; Smith, Barbara; Mahairaki, Vasiliki; Riley Richardson, M; Mulka, Kathleen R; Lane, Andrew P; Klein, Sabra L; Pekosz, Andrew; Brayton, Cory; Mankowski, Joseph L; Luirink, Joen; Villano, Jason S; Witwer, Kenneth W.
Afiliação
  • Jiang L; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Driedonks TAP; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Jong WSP; Abera Bioscience AB, Uppsala, Sweden.
  • Dhakal S; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Bart van den Berg van Saparoea H; Abera Bioscience AB, Uppsala, Sweden.
  • Sitaras I; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Zhou R; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Caputo C; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Littlefield K; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Lowman M; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Chen M; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Lima G; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Gololobova O; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Smith B; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Mahairaki V; Department of Genetic Medicine and The Richman Family Precision Medicine Centre of Excellence in Alzheimer's Disease Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Riley Richardson M; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Mulka KR; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Lane AP; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Klein SL; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Pekosz A; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Brayton C; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Mankowski JL; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Luirink J; Department of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Villano JS; Abera Bioscience AB, Uppsala, Sweden.
  • Witwer KW; Department of Molecular Microbiology, Amsterdam Institute for Molecules Medicines and Systems (AIMMS), Vrije Universiteit, Amsterdam, The Netherlands.
J Extracell Vesicles ; 11(3): e12192, 2022 03.
Article em En | MEDLINE | ID: mdl-35289114
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 4_TD Base de dados: MEDLINE Assunto principal: Vacinas Virais / Vesículas Extracelulares / COVID-19 Aspecto: Patient_preference Limite: Animals / Humans Idioma: En Revista: J Extracell Vesicles Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 4_TD Base de dados: MEDLINE Assunto principal: Vacinas Virais / Vesículas Extracelulares / COVID-19 Aspecto: Patient_preference Limite: Animals / Humans Idioma: En Revista: J Extracell Vesicles Ano de publicação: 2022 Tipo de documento: Article