Segmental and descending control of primary afferent input to the spinal lamina X.
Pain
; 163(10): 2014-2020, 2022 10 01.
Article
em En
| MEDLINE
| ID: mdl-35297816
ABSTRACT
ABSTRACT Despite being involved in a number of functions, such as nociception and locomotion, spinal lamina X remains one of the least studied central nervous system regions. Here, we show that Aδ- and C-afferent inputs to lamina X neurons are presynaptically inhibited by homo- and heterosegmental afferents as well as by descending fibers from the corticospinal tract, dorsolateral funiculus, and anterior funiculus. Activation of descending tracts suppresses primary afferent-evoked action potentials and also elicits excitatory (mono- and polysynaptic) and inhibitory postsynaptic responses in lamina X neurons. Thus, primary afferent input to lamina X is subject to both spinal and supraspinal control being regulated by at least 5 distinct pathways.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nociceptividade
/
Substância Cinzenta
Idioma:
En
Revista:
Pain
Ano de publicação:
2022
Tipo de documento:
Article