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Protein kinase C targeting of luminal (T-47D), luminal/HER2-positive (BT474), and triple negative (HCC1806) breast cancer cells in-vitro with AEB071 (Sotrastaurin) is efficient but mediated by subtype specific molecular effects.
Albert, Veruschka; Piendl, Gerhard; Yousseff, Dali; Lammert, Hedwig; Hummel, Michael; Ortmann, Olaf; Jagla, Wolfgang; Gaumann, Andreas; Wege, Anja K; Brockhoff, Gero.
Afiliação
  • Albert V; Department of Gynecology and Obstetrics, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
  • Piendl G; Department of Gynecology and Obstetrics, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
  • Yousseff D; Institute of Pathology, Kaufbeuren, Germany.
  • Lammert H; Institute of Pathology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Hummel M; Institute of Pathology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Ortmann O; Department of Gynecology and Obstetrics, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
  • Jagla W; Institute of Pathology, Kaufbeuren, Germany.
  • Gaumann A; Institute of Pathology, Kaufbeuren, Germany.
  • Wege AK; Department of Gynecology and Obstetrics, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
  • Brockhoff G; Department of Gynecology and Obstetrics, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany. gero.brockhoff@ukr.de.
Arch Gynecol Obstet ; 306(4): 1197-1210, 2022 10.
Article em En | MEDLINE | ID: mdl-35298675
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Quinase C / Neoplasias da Mama Limite: Female / Humans Idioma: En Revista: Arch Gynecol Obstet Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Quinase C / Neoplasias da Mama Limite: Female / Humans Idioma: En Revista: Arch Gynecol Obstet Ano de publicação: 2022 Tipo de documento: Article