Managing the Steady State Chromatin Landscape by Nucleosome Dynamics.
Annu Rev Biochem
; 91: 183-195, 2022 06 21.
Article
em En
| MEDLINE
| ID: mdl-35303789
ABSTRACT
Gene regulation arises out of dynamic competition between nucleosomes, transcription factors, and other chromatin proteins for the opportunity to bind genomic DNA. The timescales of nucleosome assembly and binding of factors to DNA determine the outcomes of this competition at any given locus. Here, we review how these properties of chromatin proteins and the interplay between the dynamics of different factors are critical for gene regulation. We discuss how molecular structures of large chromatin-associated complexes, kinetic measurements, and high resolution mapping of protein-DNA complexes in vivo set the boundary conditions for chromatin dynamics, leading to models of how the steady state behaviors of regulatory elements arise.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Nucleossomos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Annu Rev Biochem
Ano de publicação:
2022
Tipo de documento:
Article