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Evaluating Therapeutic Activity of Galectin-1 in Sarcolemma Repair of Skeletal Muscle.
Vallecillo-Zúniga, Mary L; Rathgeber, Matthew; Poulson, Daniel; Kartchner, Braden; Luddington, Jacob; Gill, Hailie; Hayes, Spencer; Teynor, Matthew; Stowell, Caleb S; Arthur, Connie M; Stowell, Sean R; Van Ry, Pam M.
Afiliação
  • Vallecillo-Zúniga ML; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
  • Rathgeber M; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
  • Poulson D; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
  • Kartchner B; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
  • Luddington J; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
  • Gill H; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
  • Hayes S; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
  • Teynor M; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
  • Stowell CS; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, USA.
  • Arthur CM; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Stowell SR; Harvard Glycomics Center, Harvard Medical School, Boston, MA, USA.
  • Van Ry PM; Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Methods Mol Biol ; 2442: 663-683, 2022.
Article em En | MEDLINE | ID: mdl-35320552
ABSTRACT
Galectin-1 is a small (14.5 kDa) multifunctional protein with cell-cell and cell-ECM adhesion due to interactions with the carbohydrate recognition domain (CRD). In two types of muscular dystrophies, this lectin protein has shown therapeutic properties, including positive regulation of skeletal muscle differentiation and regeneration. Both Duchenne and limb-girdle muscular dystrophy 2B (LGMD2B) are subtypes of muscular dystrophies characterized by deficient membrane repair, muscle weakness, and eventual loss of ambulation. This chapter explains confocal techniques such as laser injury, calcium imaging, and galectin-1 localization to examine the effects of galectin-1 on membrane repair in injured LGMD2B models.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcolema / Galectina 1 / Distrofia Muscular do Cíngulo dos Membros Limite: Humans Idioma: En Revista: Methods Mol Biol Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcolema / Galectina 1 / Distrofia Muscular do Cíngulo dos Membros Limite: Humans Idioma: En Revista: Methods Mol Biol Ano de publicação: 2022 Tipo de documento: Article