A new class of antimalarial drugs: derivatives of benzothiopyrans.
J Med Chem
; 21(7): 643-9, 1978 Jul.
Article
em En
| MEDLINE
| ID: mdl-353282
ABSTRACT
A series of substituted benzothiopyrans was synthesized and examined for antimalarial activity. Some were found to be active and curative at dose levels of 160--360 mg/kg against Plasmodium berghei in mice. Afew observations concerning structure-activity relationships were made. The benzothiopyrans were prepared by treatment of either the gem-dichloro- or the thionothioflavone intermediate with various primary amines. The thionothioflavone intermediates were made from thioflavones. Condensation of thiophenols with benzoyl acetates gave the thioflavones.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Benzopiranos
/
Antimaláricos
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
1978
Tipo de documento:
Article