Long-term outcomes of children with neonatal transfer: the Japan Environment and Children's Study.
Eur J Pediatr
; 181(6): 2501-2511, 2022 Jun.
Article
em En
| MEDLINE
| ID: mdl-35333975
ABSTRACT
This study aimed to evaluate the association of neonatal transfer with the risk of neurodevelopmental outcomes at 3 years of age. Data were obtained from the Japan Environment and Children's Study. A general population of 103,060 pregnancies with 104,062 fetuses was enrolled in the study in 15 Regional Centers between January 2011 and March 2014. Live-born singletons at various gestational ages, including term infants, without congenital anomalies who were followed up until 3 years were included. Neurodevelopmental impairment was assessed using the Ages and Stages Questionnaire, third edition (ASQ-3) at 3 years of age. Logistic regression was used to estimate the adjusted risk and 95% confidence interval (CI) for newborns with neonatal transfer. Socioeconomic and perinatal factors were included as potential confounders in the analysis. Among 83,855 live-born singletons without congenital anomalies, 65,710 children were studied. Among them, 2780 (4.2%) were transferred in the neonatal period. After adjustment for potential confounders, the incidence of neurodevelopmental impairment (scores below the cut-off value of all 5 domains in the ASQ-3) was higher in children with neonatal transfer compared with those without neonatal transfer (communication 6.5% vs 3.5%, OR 1.42, 95% CI 1.19-1.70; gross motor 7.6% vs 4.0%, OR 1.26, 95% CI 1.07-1.49; fine motor 11.3% vs 7.1%, OR 1.19, 95% CI 1.03-1.36; problem solving 10.8% vs 6.8%, OR 1.29, 95% CI 1.12-1.48; and personal-social 6.2% vs 2.9%, OR 1.52, 95% CI 1.26-1.83). Conclusion:
Neonatal transfer was associated with a higher risk of neurodevelopmental impairment at 3 years of age. What is Known ⢠Neonatal transfer after birth in preterm infants is associated with adverse short-term outcomes. ⢠Long-term outcomes of outborn infants with neonatal transfer in the general population remain unclear. What is New ⢠This study suggests that neonatal transfer at birth is associated with an increased risk of neurodevelopmental impairment. ⢠Efforts for referring high-risk pregnant women to higher level centers may reduce the incidence of neonatal transfer, leading to improved neurological outcomes in the general population.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Newborn
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Pregnancy
País/Região como assunto:
Asia
Idioma:
En
Revista:
Eur J Pediatr
Ano de publicação:
2022
Tipo de documento:
Article