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Lymphadenectomy in Primary Fallopian Tube Cancer is Associated with Improved Survival.
Xiao, Yao; Liu, Yue-Xi; Li, Ruo-Nan; Wei, Xing; Wang, Qing-Miao; Gu, Qiu-Ying; Linghu, Hua.
Afiliação
  • Xiao Y; Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Liu YX; Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Li RN; Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Wei X; Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Wang QM; Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Gu QY; Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Linghu H; Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
J Invest Surg ; 35(6): 1417-1423, 2022 Jun.
Article em En | MEDLINE | ID: mdl-35344678
BACKGROUND AND OBJECTIVES: Primary fallopian tube cancer (PFTC) shares the same diagnostic and management guidelines with epithelial ovarian cancer (EOC). The LION trail raised concerns regarding the role of systematic pelvic and para-aortic lymphadenectomy during debulking surgery. We aimed to evaluate the significance of lymphadenectomy in PFTC survival. METHODS: This retrospective study analyzed the clinical features and survival of patients with PFTC who underwent primary surgery in our center between January 2013 and October 2020. RESULTS: Sixty-one patients diagnosed with PFTC were included in the study. Twenty-five (41.0%, 25/61) were diagnosed with FIGO (International Federation of Gynecology and Obstetrics) stages I/II and 36 (59.0%, 36/61) were diagnosed with stage III/IV. Twenty-nine (47.5%, 29/61) underwent pelvic lymphadenectomy with or without para-aortic lymphadenectomy, among which 12 (41.4%, 12/29) had lymph node metastasis confirmed by postoperative pathology. The mean progression-free survival was 60.4 months in the lymphadenectomy group and 37.8 months in the no-lymphadenectomy group (p = 0.042, HR 0.374, 95% CI 0.145-0.966). CONCLUSIONS: PFTC is often diagnosed earlier and has a better prognosis than EOC. Most patients with PFTC would benefit from lymphadenectomy. However, the extent to which this association translates to a more diverse population needs to be further identified.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Neoplasias das Tubas Uterinas Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: J Invest Surg Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Neoplasias das Tubas Uterinas Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: J Invest Surg Ano de publicação: 2022 Tipo de documento: Article