PBK modelling of topical application and characterisation of the uncertainty of C<sub>max</sub> estimate: A case study approach.

Li, Hequn; Reynolds, Joe; Sorrell, Ian; Sheffield, David; Pendlington, Ruth; Cubberley, Richard; Nicol, Beate

PBK modelling of topical application and characterisation of the uncertainty of C_max estimate: A case study approach.

Li, Hequn; Reynolds, Joe; Sorrell, Ian; Sheffield, David; Pendlington, Ruth; Cubberley, Richard; Nicol, Beate.

Afiliação

Li H; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK. Electronic address: Hequn.Li@unilever.com.
Reynolds J; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK.
Sorrell I; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK.
Sheffield D; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK.
Pendlington R; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK.
Cubberley R; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK.
Nicol B; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK.

Toxicol Appl Pharmacol ; 442: 115992, 2022 05 01.

Article em En | MEDLINE | ID: mdl-35346730

Assuntos

Fígado; Modelos Biológicos; Teorema de Bayes; Humanos; Cinética; Medição de Risco/métodos; Incerteza

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fígado / Modelos Biológicos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2022 Tipo de documento: Article

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