Concussion-Associated Gene Variant COMT rs4680 Is Associated With Elite Rugby Athlete Status.
Clin J Sport Med
; 33(5): e145-e151, 2023 09 01.
Article
em En
| MEDLINE
| ID: mdl-35350037
ABSTRACT
OBJECTIVE:
Concussions are common match injuries in elite rugby, and reports exist of reduced cognitive function and long-term health consequences that can interrupt or end a playing career and produce continued ill health. The aim of this study was to investigate the association between elite rugby status and 8 concussion-associated risk polymorphisms. We hypothesized that concussion-associated risk genotypes and alleles would be underrepresented in elite rugby athletes compared with nonathletes.DESIGN:
A case-control genetic association study.SETTING:
Institutional (university).PARTICIPANTS:
Elite White male rugby athletes [n = 668, mean (SD) height 1.85 (0.07) m, mass 102 (12) kg, and age 29 (7) years] and 1015 nonathlete White men and women (48% men).INTERVENTIONS:
Genotype was the independent variable, obtained by PCR of genomic DNA using TaqMan probes. MAIN OUTCOMEMEASURE:
Elite athlete status with groups compared using χ 2 and odds ratio (OR).RESULTS:
The COMT rs4680 Met/Met (AA) genotype, Met allele possession, and Met allele frequency were lower in rugby athletes (24.8%, 74.6%, and 49.7%, respectively) than nonathletes (30.2%, 77.6%, and 54.0%; P < 0.05). The Val/Val (GG) genotype was more common in elite rugby athletes than nonathletes (OR 1.39, 95% confidence interval 1.04-1.86). No other polymorphism was associated with elite athlete status.CONCLUSIONS:
Elite rugby athlete status is associated with COMT rs4680 genotype that, acting pleiotropically, could affect stress resilience and behavioral traits during competition, concussion risk, and/or recovery from concussion. Consequently, assessing COMT rs4680 genotype might aid future individualized management of concussion risk among athletes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Concussão Encefálica
/
Futebol Americano
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin J Sport Med
Ano de publicação:
2023
Tipo de documento:
Article