CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells.

Bommi-Reddy, Archana; Park-Chouinard, Sungmi; Mayhew, David N; Terzo, Esteban; Hingway, Aparna; Steinbaugh, Michael J; Wilson, Jonathan E; Sims, Robert J; Conery, Andrew R

Bommi-Reddy, Archana; Park-Chouinard, Sungmi; Mayhew, David N; Terzo, Esteban; Hingway, Aparna; Steinbaugh, Michael J; Wilson, Jonathan E; Sims, Robert J; Conery, Andrew R.

Afiliação

Bommi-Reddy A; Constellation Pharmaceuticals, a Morphosys Company, Cambridge, Massachusetts, United States of America.
Park-Chouinard S; Constellation Pharmaceuticals, a Morphosys Company, Cambridge, Massachusetts, United States of America.
Mayhew DN; Constellation Pharmaceuticals, a Morphosys Company, Cambridge, Massachusetts, United States of America.
Terzo E; Constellation Pharmaceuticals, a Morphosys Company, Cambridge, Massachusetts, United States of America.
Hingway A; Constellation Pharmaceuticals, a Morphosys Company, Cambridge, Massachusetts, United States of America.
Steinbaugh MJ; Constellation Pharmaceuticals, a Morphosys Company, Cambridge, Massachusetts, United States of America.
Wilson JE; Constellation Pharmaceuticals, a Morphosys Company, Cambridge, Massachusetts, United States of America.
Sims RJ; Constellation Pharmaceuticals, a Morphosys Company, Cambridge, Massachusetts, United States of America.
Conery AR; Constellation Pharmaceuticals, a Morphosys Company, Cambridge, Massachusetts, United States of America.

PLoS One ; 17(3): e0262378, 2022.

Article em En | MEDLINE | ID: mdl-35353838

Assuntos

Neoplasias da Mama; Receptores de Estrogênio; Acetiltransferases; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Proteína de Ligação a CREB/genética; Proteína de Ligação a CREB/metabolismo; Linhagem Celular Tumoral; Proliferação de Células; Proteína p300 Associada a E1A/genética; Feminino; Fator 3-alfa Nuclear de Hepatócito/genética; Humanos; Células MCF-7; Receptores de Estrogênio/genética; Receptores de Estrogênio/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Receptores de Estrogênio Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: PLoS One Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google