Photoredox/Copper Dual-Catalyzed Benzylic C-H Esterification via Radical-Polar Crossover.
Org Lett
; 24(14): 2679-2683, 2022 04 15.
Article
em En
| MEDLINE
| ID: mdl-35357841
ABSTRACT
Herein, we report a distinctive photoredox/copper dual-catalyzed esterification of benzylic C-H bonds through the combination of photoredox-mediated hydrogen atom transfer and Cu(II)-mediated radical-polar crossover. This methodology demonstrates a high functional group tolerance (>40 examples) and moderate to good yields with structurally diverse benzylic C-H substrates. Notably, stoichiometric amounts of carboxylic acids are used as coupling partners, which allows the synthesis of structurally diverse benzylic esters and the late-stage functionalization of pharmaceuticals.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cobre
/
Hidrogênio
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2022
Tipo de documento:
Article