The role of irisin in metabolic flexibility: Beyond adipose tissue browning.
Drug Discov Today
; 27(8): 2261-2267, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35364272
ABSTRACT
Metabolic flexibility is the ability to adapt to physiological and environmental changes in metabolic demand. Irisin was originally discovered as an exercise-induced myokine involved in fat browning. In this review, we summarize emerging evidence for the roles of irisin in regulating glucose metabolism and insulin sensitivity in skeletal muscle, neuroplasticity and satiety in central nervous system, ß cell function and insulin secretion in the pancreas, bone remodeling, and adipose tissue function, which together orchestrate whole-body metabolic flexibility. Irisin is a key communicating mediator between skeletal muscle and other organs, and its manipulation could be a promising therapeutic strategy for treating obesity and related metabolic disorders.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Fibronectinas
Limite:
Humans
Idioma:
En
Revista:
Drug Discov Today
Ano de publicação:
2022
Tipo de documento:
Article