Transsulfuration, minor player or crucial for cysteine homeostasis in cancer.
Trends Cell Biol
; 32(9): 800-814, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35365367
ABSTRACT
Cysteine, a thiol-containing amino acid, is crucial for the synthesis of sulfur-containing biomolecules that control multiple essential cellular activities. Altered cysteine metabolism has been linked to numerous driver oncoproteins and tumor suppressors, as well as to malignant traits in cancer. Cysteine can be acquired from extracellular sources or synthesized de novo via the transsulfuration (TSS) pathway. Limited availability of cystine in tumor interstitial fluids raises the possible dependency on de novo cysteine synthesis via TSS. However, the contribution of TSS to cancer metabolism remains highly contentious. Based on recent findings, we provide new perspectives on this crucial but understudied metabolic pathway in cancer.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cisteína
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
2022
Tipo de documento:
Article