Role of Aspirin in Gastric Cancer Prevention.
Cancer Prev Res (Phila)
; 15(4): 213-215, 2022 04 01.
Article
em En
| MEDLINE
| ID: mdl-35373259
ABSTRACT
The role of aspirin in cancer prevention has been well described for multiple cancers, with strong data for gastrointestinal cancers. Studies, primarily conducted in colorectal cancer, suggest that aspirin exerts its cancer-preventive effects through the inhibition of gastrointestinal inflammation. Compared with colorectal cancer, the role of aspirin in gastric cancer prevention is less well described, however it stands to reason that aspirin and/or other nonsteroidal anti-inflammatory drugs may inhibit gastric cancer progression through the inhibition of COX-2. As discussed in this issue of Cancer Prevention Research, aspirin may prevent gastric cancer, albeit it appears to exert a disparate effect in men and women, the reason for which remain unclear. These results expand upon prior studies by prospectively examining aspirin use at a wider range of doses and durations in non-Asian participants and lend support to observations from previously conducted studies in Asian populations. See related article, p. 265.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Neoplasias Gastrointestinais
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cancer Prev Res (Phila)
Ano de publicação:
2022
Tipo de documento:
Article