Oxidative stress, DNA damage, and gene expression induced by flufiprole enantiomers in the earthworms (Eisenia fetida).
Comp Biochem Physiol C Toxicol Pharmacol
; 257: 109341, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-35381367
ABSTRACT
To evaluate flufiprole enantiomers ecotoxicology and early warning to earthworms in the soil, the effect of flufiprole enantiomers on the activity of antioxidative enzymes (superoxide dismutase, SOD; catalase, CAT; peroxidase, POD), malondialdehyde (MDA) content, DNA damage and expression level of target genes (SOD, TCTP, l-rRNA, and HSP90) have been investigated. Compared to the controls, the activities of SOD, CAT, POD, and MDA content were first inhibited and then stimulated by all concentrations of flufiprole enantiomers in 28 days. The olive tail moment (OTM) value was maximum on the 14th day, then decreased gradually, and the higher the concentration, the slower the decrease. The expression level of the SOD and TCTP genes increased first and then decreased. In conclusion, the toxicity of flufiprole enantiomers to earthworms is R-(+)- flufiprole >Rac-(±)- flufiprole >S-(-)- flufiprole. The SOD could be the key biomarker for monitoring the risk of flufiprole enantiomers.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligoquetos
/
Poluentes do Solo
Limite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol C Toxicol Pharmacol
Ano de publicação:
2022
Tipo de documento:
Article