Lip mesotherapy with dexpanthenol in the treatment of isotretinoin-induced cheilitis.
J Cosmet Dermatol
; 21(10): 4684-4690, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-35426210
ABSTRACT
INTRODUCTION:
Cheilitis is the most common mucocutaneous side effect of isotretinoin (ISO). Dexpanthenol (DXP) increases fibroblast proliferation and re-epithelialization in wound healing. We aimed to investigate the effect of DXP-mesotherapy in ISO-induced cheilitis in this study.METHODS:
This study was conducted on patients who had been using ISO (0.5-1 mg/kg/day) for at least 2 months. Twenty-five patients who administered DXP-mesotherapy (mesotherapy group) and 33 patients without the procedure (control group, only ointment) participated in this study. All patients were prescribed only hamamelis virginiana distillate in ointment form as a lip balm. The efficacy of the treatment was interpreted by the change in lip balm use frequency, quality of life, and Isotretinoin Cheilitis Grading Scale (ICGS).RESULTS:
There was a statistically significant decrease in all ICGS-subgroups scores in the mesotherapy group after 1 month compared with the baseline (p = <0.001), although in the controls, erythema, crust, and fissure scores significantly increased (p = 0.001, p = 0.002).While there was no difference between the groups in terms of ICGS total scores at baseline, there was a significant difference after 1 month in favor of the mesotherapy group (p < 0.001). In the mesotherapy group, lip balms were needed significantly less frequently and there was a significant improvement in quality of life compared with both the control group and at baseline after 1 month (both; p < 0.001). On the other hand, the control patients suffered more from cheilitis and dryness than at baseline (p < 0.001).CONCLUSION:
Dexpanthenol-mesotherapy seems to be a safe, and so effective method in management of ISO-related cheilitis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Queilite
/
Mesoterapia
Aspecto:
Patient_preference
Limite:
Humans
Idioma:
En
Revista:
J Cosmet Dermatol
Ano de publicação:
2022
Tipo de documento:
Article