Impact of contact inhibition on collective cell migration and proliferation.

ABSTRACT

Contact inhibition limits migration and proliferation of cells in cell colonies. We consider a multiphase field model to investigate the growth dynamics of a cell colony, composed of proliferating cells. The model takes into account the mechanism of contact inhibition of proliferation by local mechanical interactions. We compare nonmigrating and migrating cells, in order to provide a quantitative characterization of the dynamics and analyze the velocity of the colony boundary for both cases. Additionally, we measure single cell velocities, number of neighbor distributions, as well as the influence of stress and age on positions of the cells and with respect to each other.