Making Antimicrobial Susceptibility Testing More Physiologically Relevant with Bicarbonate?
Antimicrob Agents Chemother
; 66(5): e0241221, 2022 05 17.
Article
em En
| MEDLINE
| ID: mdl-35435706
ABSTRACT
Azithromycin is a clinically important drug for treating invasive salmonellosis despite poor activity in laboratory assays for MIC. Addition of the main buffer in blood, bicarbonate, has been proposed for more physiologically relevant and more predictive testing conditions. However, we show here that bicarbonate-triggered lowering of azithromycin MIC is entirely due to alkalization of insufficiently buffered media. In addition, bicarbonate is unlikely to be altering efflux pump activity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azitromicina
/
Anti-Infecciosos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2022
Tipo de documento:
Article