Hunting out the autophagic problem in Huntington disease.
Autophagy
; 18(12): 3031-3032, 2022 12.
Article
em En
| MEDLINE
| ID: mdl-35468035
ABSTRACT
Huntington disease is an inherited, progressive, incurable neurodegenerative disorder that primarily affects cells in the brain. Although the genetic basis for this condition has been known for nearly 30 years, how this causes disease is still unresolved. Of late there has been increasing evidence suggesting that dysfunction in macroautophagic/autophagic pathways may contribute to cellular dysfunction and death. In our recent work we highlight more precisely how and where this problem might arise in this pathway using directly reprogrammed neurons.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Huntington
/
Doenças Neurodegenerativas
Limite:
Humans
Idioma:
En
Revista:
Autophagy
Ano de publicação:
2022
Tipo de documento:
Article