[Definition and Management of the Immune Tolerance Phase in Chronic Hepatitis B].
Korean J Gastroenterol
; 79(4): 156-160, 2022 04 25.
Article
em Ko
| MEDLINE
| ID: mdl-35473773
ABSTRACT
In the natural course of chronic hepatitis B, the immune tolerance phase is characterized by HBeAg positivity, very high levels of HBV DNA, and persistent normal alanine aminotransferase. The international guideline recommendation for patients in this phase is observation without antiviral treatment because of the low risk of disease progression and the lack of effective antiviral agents. However, recent retrospective studies have shown that progression to hepatic fibrosis and hepatocellular carcinoma may occur in patients who are in the immune tolerance phase. Despite the conceptual definition and clinical diagnostic criteria for this phase, it is difficult to accurately diagnose the true immune tolerance phase. Therefore, we should pay attention to the clinical evaluation and interpretation of the immune tolerance phase and understand the clinical situations in which antiviral treatments should be considered.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hepatite B Crônica
/
Neoplasias Hepáticas
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
/
Guideline
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Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean J Gastroenterol
Ano de publicação:
2022
Tipo de documento:
Article