[Acute kidney injury and COVID-19: lung-kidney crosstalk during severe inflammation]. / Akute Nierenschädigung und COVID-19: pulmorenaler Crosstalk unter massiver Inflammation.
Med Klin Intensivmed Notfmed
; 117(5): 342-348, 2022 Jun.
Article
em De
| MEDLINE
| ID: mdl-35476144
ABSTRACT
Coronavirus disease 2019 (COVID-19)-associated acute kidney injury (AKI) is common in critically ill patients. Renal tropism of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) appears to play only a minor role, whereas the pathological inflammatory response associated with severe COVID-19 is highly relevant. Both the consequences of invasive ventilation and acute respiratory distress syndrome (ARDS) caused by COVID-19 have a significant impact on the pathogenesis of AKI. High ventilation pressures compromise renal perfusion and, thus, may contribute to the development of AKI. The inflammatory response caused by ARDS, as well as the endothelial dysfunction typical of COVID-19 in combination with hypercoagulability are further factors that affect the kidney.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Desconforto Respiratório
/
Injúria Renal Aguda
/
COVID-19
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
De
Revista:
Med Klin Intensivmed Notfmed
Ano de publicação:
2022
Tipo de documento:
Article