Factors that impact on women's decision-making around prenatal genomic tests: An international discrete choice survey.
Prenat Diagn
; 42(7): 934-946, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35476801
ABSTRACT
OBJECTIVE:
We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries.METHODS:
Five test attributes were identified as being important for decision-making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women from eight countries who delivered a baby in the previous 24 months completed a DCE presenting these scenarios. Choices were modeled using conditional logit regression analysis.RESULTS:
Surveys from 1239 women (Australia n = 178; China n = 179; Denmark n = 88; Netherlands n = 177; Singapore n = 90; Sweden n = 178; UK n = 174; USA n = 175) were analyzed. The key attribute affecting preferences was a test with the highest diagnostic yield (p < 0.01). Women preferred tests with short turnaround times (p < 0.01), and tests reporting variants of uncertain significance (VUS; p < 0.01) and secondary findings (SFs; p < 0.01). Several country-specific differences were identified, including time to get a result, who explains the result, and the return of VUS and SFs.CONCLUSION:
Most women want maximum information from prenatal genomic tests, but our findings highlight country-based differences. Global consensus on how to return uncertain results is not necessarily realistic or desirable.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento de Escolha
/
Preferência do Paciente
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Qualitative_research
/
Systematic_reviews
Aspecto:
Patient_preference
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Prenat Diagn
Ano de publicação:
2022
Tipo de documento:
Article