A Germanium Catalyst Accelerates the Photoredox α-C(sp3)-H Alkylation of Primary Amines.
Org Lett
; 24(18): 3325-3330, 2022 05 13.
Article
em En
| MEDLINE
| ID: mdl-35486160
ABSTRACT
Site-selective C(sp3)-H functionalizations using photoredox catalysis (PC) and hydrogen atom transfer (HAT) catalysis have received increasing attention. Here, we report a Ph2GeCl2 cocatalyst that greatly improves the yield of α-C(sp3)-H alkylation of primary amines catalyzed by a PC-HAT hybrid system. The α-position of the amino group selectively reacted even when weaker C-H bonds existed in the substrates. This finding may help the design of a novel site-selective hybrid catalysis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminas
/
Germânio
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2022
Tipo de documento:
Article