Mitochondrial dysfunction in anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) immune-mediated necrotising myopathy.
Neuromuscul Disord
; 32(5): 441-444, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-35487868
ABSTRACT
Mitochondrial dysfunction is a plausible cause of muscle fibre damage in a number of myopathies including immune-mediated necrotising myopathy. However, histopathological evidence of mitochondrial dysfunction is not often described in immune-mediated necrotising myopathy and, when present, it is often attributed to patient age. The purpose of this study was to describe features of mitochondrial dysfunction on muscle biopsy in anti-3hydroxy-3-methylglutaryl-CoA reductase immune-mediated necrotising myopathy and explore whether these features are age-related. In this observational case control study, a statistically significant increase in the number of muscle fibres with increased lipid content (pâ¯=â¯0.004) and cytochrome c oxidase-negative/succinate dehydrogenase-positive fibres (pâ¯=â¯0.037) in anti-3hydroxy-3-methylglutaryl-coenzyme immune-mediated necrotising myopathy was found compared to age-matched controls. Therefore, histopathological features of mitochondrial dysfunction are more frequent in anti-3hydroxy-3-methylglutaryl-coenzyme immune-mediated necrotising myopathy than aged-matched controls and therefore, may be contributing to the pathogenesis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
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Inibidores de Hidroximetilglutaril-CoA Redutases
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Doenças Musculares
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Miosite
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Neuromuscul Disord
Ano de publicação:
2022
Tipo de documento:
Article