Your browser doesn't support javascript.
loading
Frequency of Depressive Disorders in Parkinson's Disease: A Systematic Review and Meta-Analysis.
Chendo, Ines; Silva, Carlos; Duarte, Gonçalo S; Prada, Luisa; Vian, João; Quintão, Ana; Voon, Valerie; Ferreira, Joaquim J.
Afiliação
  • Chendo I; Psychiatry Department, Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal.
  • Silva C; Clínica Universitária de Psiquiatria e Psicologia Médica, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
  • Duarte GS; CNS - Campus Neurológico, Torres Vedras, Portugal.
  • Prada L; Psychiatry Department, Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal.
  • Vian J; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
  • Quintão A; Instituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal.
  • Voon V; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
  • Ferreira JJ; Instituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal.
J Parkinsons Dis ; 12(5): 1409-1418, 2022.
Article em En | MEDLINE | ID: mdl-35491801
BACKGROUND: Depressive disorders are recognized as a common neuropsychiatric disorder of Parkinson's disease (PD). Reported frequencies vary widely among studies and depend on the diagnostic criteria, the methods of ascertainment used, and the population sampled. OBJECTIVE: We aimed to evaluate the frequency of depressive disorders in PD and to investigate the relationship with PD clinical variables. METHODS: A systematic review and meta-analysis of observational studies (community-based, prospective and retrospective cohort, case-control, and cross-sectional studies) reporting the frequency of depressive disorders in PD patients. RESULTS: Electronic database search wielded 3,536 articles; an additional 91 were identified through citation chaining. 163 full-text articles were assessed for eligibility. Of these, 49 met the inclusion criteria for our analysis. The pooled frequency of depressive disorders was 30.7% (95% confidence interval [CI] 25.6 to 36.2; I2 = 95%; 49 studies; combined n = 10,039). The pooled frequency of major depressive disorder was 14.0% (95% CI 10.5 to 18.5; I2 = 88%; 23 studies; combined n = 5,218). Subgroup/meta-regression analyses were conducted to investigate the relationship between frequency and study inclusion criteria, methodology used for diagnosis, and study design. We found a statistically significant correlation between study design and depressive disorders frequency (ranging from 8% in the community-based study to 44% in the retrospective studies) and a statistically significant positive correlation between mean baseline PD duration and major depressive disorder frequency. CONCLUSION: The current meta-analysis found a global frequency of depressive disorders of 30.7% and major depressive disorder of 14.0%. Study design influenced the frequency of depressive disorders in PD. Mean baseline PD duration and major depressive disorder frequency were positively correlated.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Transtorno Depressivo Maior Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: J Parkinsons Dis Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Transtorno Depressivo Maior Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: J Parkinsons Dis Ano de publicação: 2022 Tipo de documento: Article