A Trade-off Between Thermostability and Binding Affinity of Anti-(4-hydroxy-3-nitrophenyl)Acetyl Antibodies During the Course of Affinity Maturation.

Nishiguchi, Akihiro; Murakami, Akikazu; Azuma, Takachika; Oda, Masayuki

Nishiguchi, Akihiro; Murakami, Akikazu; Azuma, Takachika; Oda, Masayuki.

Afiliação

Nishiguchi A; Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Shimogamo Hangi-cho, Sakyo-ku, Kyoto, 606-8522, Japan.
Murakami A; Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8504, Japan.
Azuma T; Antibody Technology Research Center, Inc, 2361-1Yamazaki, Noda, Chiba, 278-0022, Japan.
Oda M; Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Shimogamo Hangi-cho, Sakyo-ku, Kyoto, 606-8522, Japan. oda@kpu.ac.jp.

Protein J ; 41(2): 293-303, 2022 04.

Article em En | MEDLINE | ID: mdl-35501455

Assuntos

Anticorpos; Afinidade de Anticorpos; Dicroísmo Circular; Termodinâmica

Palavras-chave

Affinity maturation; Antigen binding; Thermostability; Trade-off between stability and affinity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Idioma: En Revista: Protein J Ano de publicação: 2022 Tipo de documento: Article

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