Computational Pipeline for Rational Drug Combination Screening in Patient-Derived Cells.

Athanasiadis, Paschalis; Ianevski, Aleksandr; Skånland, Sigrid S; Aittokallio, Tero

Athanasiadis, Paschalis; Ianevski, Aleksandr; Skånland, Sigrid S; Aittokallio, Tero.

Afiliação

Athanasiadis P; Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Ianevski A; Oslo Centre for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway.
Skånland SS; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Aittokallio T; Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

Methods Mol Biol ; 2449: 327-348, 2022.

Article em En | MEDLINE | ID: mdl-35507270

Assuntos

Ecossistema; Neoplasias; Biologia Computacional/métodos; Combinação de Medicamentos; Avaliação Pré-Clínica de Medicamentos/métodos; Sinergismo Farmacológico; Humanos; Neoplasias/tratamento farmacológico

Palavras-chave

Drug combinations; High-throughput screening; Precision oncology; Predictive modeling; Synergy scoring; Toxic effects

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ecossistema / Neoplasias Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Methods Mol Biol Ano de publicação: 2022 Tipo de documento: Article

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