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The Protective Effects of Osteocyte-Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging.
Jiang, Ya-Ling; Wang, Zhen-Xing; Liu, Xi-Xi; Wan, Mei-Dan; Liu, Yi-Wei; Jiao, Bin; Liao, Xin-Xin; Luo, Zhong-Wei; Wang, Yi-Yi; Hong, Chun-Gu; Tan, Yi-Juan; Weng, Ling; Zhou, Ya-Fang; Rao, Shan-Shan; Cao, Jia; Liu, Zheng-Zhao; Wan, Teng-Fei; Zhu, Yuan; Xie, Hui; Shen, Lu.
Afiliação
  • Jiang YL; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Wang ZX; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Liu XX; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Wan MD; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Liu YW; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Jiao B; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Liao XX; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan, 410008, China.
  • Luo ZW; Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, Hunan, 410008, China.
  • Wang YY; Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, Hunan, 410008, China.
  • Hong CG; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, China.
  • Tan YJ; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Weng L; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, Hunan, 410008, China.
  • Zhou YF; Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, Hunan, 410008, China.
  • Rao SS; Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, Hunan, 410008, China.
  • Cao J; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, China.
  • Liu ZZ; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Wan TF; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Zhu Y; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Xie H; Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Shen L; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Adv Sci (Weinh) ; 9(17): e2105316, 2022 06.
Article em En | MEDLINE | ID: mdl-35508803
ABSTRACT
Both Alzheimer's disease (AD) and osteoporosis (OP) are common age-associated degenerative diseases and are strongly correlated with clinical epidemiology. However, there is a lack of clear pathological relationship between the brain and bone in the current understanding. Here, it is found that young osteocyte, the most abundant cells in bone, secretes extracellular vesicles (OCYYoung -EVs) to ameliorate cognitive impairment and the pathogenesis of AD in APP/PS1 mice and model cells. These benefits of OCYYoung -EVs are diminished in aged osteocyte-derived EVs (OCYAged -EVs). Based on the self-constructed OCY-EVs tracer transgenic mouse models and the in vivo fluorescent imaging system, OCY-EVs have been observed to be transported to the brain under physiological and pathological conditions. In the hippocampal administration of Aß40 induced young AD model mice, the intramedullary injection of Rab27a-shRNA adenovirus inhibits OCYYoung -EVs secretion from bone and aggravates cognitive impairment. Proteomic quantitative analysis reveals that OCYYoung -EVs, compared to OCYAged -EVs, enrich multiple protective factors of AD pathway. The study uncovers the role of OCY-EV as a regulator of brain health, suggesting a novel mechanism in bone-brain communication.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Vesículas Extracelulares Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Adv Sci (Weinh) Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Vesículas Extracelulares Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Adv Sci (Weinh) Ano de publicação: 2022 Tipo de documento: Article