Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization.
Angew Chem Int Ed Engl
; 61(28): e202203390, 2022 07 11.
Article
em En
| MEDLINE
| ID: mdl-35510306
ABSTRACT
A Ru(bpy)3 Cl2 photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene-containing pharmacological agents, including combretastatin A-4 (CA-4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA-4 analog Res-3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
/
Antineoplásicos
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2022
Tipo de documento:
Article